SYSTEMIC REGULATION OF RETINAL MEDIUM-CHAIN FATTY ACID OXIDATION REPLETES TCA CYCLE FLUX IN OXYGEN-INDUCED RETINOPATHY

Systemic regulation of retinal medium-chain fatty acid oxidation repletes TCA cycle flux in oxygen-induced retinopathy

Abstract Activation of anaplerosis takes away glutamine from the biosynthetic pathways to the energy-producing TCA cycle.Especially, induction of hyperoxia driven anaplerosis in neurovascular tissues such as the retina during early stages of development could deplete biosynthetic precursors from newly proliferating endothelial cells impeding physio

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Cerebral salt wasting following traumatic brain injury

Hyponatraemia is the ford tridon most commonly encountered electrolyte disturbance in neurological high dependency and intensive care units.Cerebral salt wasting (CSW) is the most elusive and challenging of the causes of hyponatraemia, and it is vital to distinguish it from the more familiar syndrome of inappropriate antidiuretic hormone (SIADH).Ma

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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

Respiratory complex I is a multi-subunit membrane protein complex that reversibly couples NADH oxidation and ubiquinone reduction with proton translocation against transmembrane potential.Complex I from Escherichia coli is among the best functionally characterized complexes, but its structure remains unknown, hindering further studies to understand

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